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The Immunological Synapse Balances T Cell Receptor Signaling and Degradation

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Science  14 Nov 2003:
Vol. 302, Issue 5648, pp. 1218-1222
DOI: 10.1126/science.1086507

Article Information

vol. 302 no. 5648 1218-1222

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History: 
  • Received for publication May 6, 2003
  • Accepted for publication August 26, 2003
  • .

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Author Information

  1. Kyeong-Hee Lee1,2,*,
  2. Aaron R. Dinner3,*,,
  3. Chun Tu1,
  4. Gabriele Campi5,
  5. Subhadip Raychaudhuri4,
  6. Rajat Varma5,
  7. Tasha N. Sims5,
  8. W. Richard Burack1,
  9. Hui Wu1,
  10. Julia Wang1,
  11. Osami Kanagawa1,
  12. Mary Markiewicz1,
  13. Paul M. Allen1,
  14. Michael L. Dustin5,,
  15. Arup K. Chakraborty3,4,6,,
  16. Andrey S. Shaw1,
  1. 1 Department of Pathology and Immunology, Washington University School of Medicine, Box 8118, 660 South Euclid, Saint Louis, MO 63110, USA.
  2. 2 Department of Immunology, Genentech, 530 Forbes Boulevard, One DNA Way, South San Francisco, CA 94080, USA.
  3. 3 Department of Chemistry, University of California, Berkeley, CA 94720, USA.
  4. 4 Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA.
  5. 5 Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University, New York, NY 10016, USA.
  6. 6 Physical Biosciences and Materials Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA.
  1. To whom correspondence should be addressed: E-mail: shaw{at}pathbox.wustl.edu (A.S.S.), arup{at}uclink.berkeley.edu (A.K.C.), and dustin{at}saturn.med.nyu.edu (M.L.D.)
  • * These authors contributed equally to this work.

  • Present address: Department of Chemistry, University of Chicago, Chicago, IL 60637, USA.

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