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In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

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Science  06 Feb 2004:
Vol. 303, Issue 5659, pp. 844-848
DOI: 10.1126/science.1092472

Article Information

vol. 303 no. 5659 844-848

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Print ISSN: 
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History: 
  • Received for publication October 10, 2003
  • Accepted for publication December 16, 2003
  • .

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Author Information

  1. Lyubomir T. Vassilev1,*,
  2. Binh T. Vu2,
  3. Bradford Graves2,
  4. Daisy Carvajal1,
  5. Frank Podlaski1,
  6. Zoran Filipovic1,
  7. Norman Kong2,
  8. Ursula Kammlott2,
  9. Christine Lukacs2,
  10. Christian Klein3,
  11. Nader Fotouhi2,
  12. Emily A. Liu2
  1. 1 Department of Discovery Oncology, Roche Research Center, Hoffmann–La Roche, Inc., Nutley, NJ 07110, USA.
  2. 2 Department of Chemistry, Roche Research Center, Hoffmann–La Roche, Inc., Nutley, NJ 07110, USA.
  3. 3 Pharma Research, Roche Diagnostics GmbH, 82372 Penzberg, Germany.
  1. * To whom correspondence should be addressed. E-mail: lyubomir.vassilev{at}roche.com

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