19 March 2004
Vol 303, Issue 5665

About The Cover

Cover image expansion

COVER The inhibitor Gleevec bound to the catalytic domain of Abl tyrosine kinase, as rendered by the program Aesop from coordinates in the Protein Data Bank. A special section, along with associated online material, describes how new technologies are being applied to overcome the challenges of drug discovery. 1795. [Image: M. Noble et al.]