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High Frequency of Mutations of the PIK3CA Gene in Human Cancers

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Science  23 Apr 2004:
Vol. 304, Issue 5670, pp. 554
DOI: 10.1126/science.1096502

Article Information

vol. 304 no. 5670 554

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Print ISSN: 
Online ISSN: 
History: 
  • Received for publication February 6, 2004
  • Accepted for publication February 27, 2004
  • .

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Author Information

  1. Yardena Samuels1,
  2. Zhenghe Wang1,
  3. Alberto Bardelli1,
  4. Natalie Silliman1,
  5. Janine Ptak1,
  6. Steve Szabo1,
  7. Hai Yan2,
  8. Adi Gazdar3,
  9. Steven M. Powell4,
  10. Gregory J. Riggins1,
  11. James K. V. Willson5,
  12. Sanford Markowitz5,
  13. Kenneth W. Kinzler1,
  14. Bert Vogelstein1,
  15. Victor E. Velculescu1,*
  1. 1 The Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA.
  2. 2 Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.
  3. 3 Hamon Center for Therapeutic Oncology Research and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  4. 4 Division of Gastroenterology/Hepatology, University of Virginia Health System, Charlottesville, VA 22908, USA.
  5. 5 Howard Hughes Medical Institute, Ireland Cancer Center, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106, USA.
  1. * To whom correspondence should be addressed. E-mail: velculescu{at}jhmi.edu

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