Contents
Vol 304, Issue 5679
Special Issue
HIV/AIDS in Asia
Introduction to special issue
News
Contents
This Week in Science
Editorial
Editors' Choice
NetWatch
Departments
Products & Materials
News of the Week
ScienceScope
Random Samples
News Focus
Letters
Books
Policy Forum
Perspectives
Review
Brevia
- DNA Methylation Is Independent of RNA Interference in Neurospora
Although double-stranded RNA participates in gene silencing by DNA methylation in plants, it is not necessary in the filamentous fungus Neurospora.
Research Article
- Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors
A ubiquitous cellular protein controls a huge family of cell surface receptors for hormones and neurotransmitters by interfering with another regulator.
Reports
- A Molecular Photodiode System That Can Switch Photocurrent Direction
A molecular photodiode formed by anchoring two helical peptides sensitive to different wavelengths of light conducts current in opposite directions depending on the wavelength used.
- Discovery of a Compact Radio Component in the Center of Supernova 1986J
Changes in the radio emissions from the core of Supernova 1986J, 20 years after its collapse, support the theoretical prediction that a black hole or neutron star is forming.
- Earthquakes Beneath the Himalayas and Tibet: Evidence for Strong Lithospheric Mantle
Earthquakes within Earth's upper mantle deep beneath the western Himalayas indicate that the mantle is unusually strong there.
- Dynamics of Slow-Moving Landslides from Permanent Scatterer Analysis
Ten years of satellite radar interferometry measurements reveal how several slow-moving landslides in California accelerated after heavy rains, especially during an El Niño year.
- Abrupt Tropical Vegetation Response to Rapid Climate Changes
Large, sudden changes in the vegetation of tropical South America occurred several decades after rapid climate shifts seen in the Northern Hemisphere during the last deglaciation.
- Antarctic Timing of Surface Water Changes off Chile and Patagonian Ice Sheet Response
A detailed climate record from a core in the southeast Pacific shows that sea surface temperatures there changed in concert with Antarctic temperatures over the past 50,000 years.
- Activation of Transcription Factor NF-κB Requires ELKS, an IκB Kinase Regulatory Subunit
A ubiquitous protein is shown to be essential for inflammation in human cells and could be a useful target for anti-inflammatory drugs.
- Computational Design of a Biologically Active Enzyme
Rationally designed mutations convert a catalytically dead ribose binding protein into an active isomerase enzyme.
- RNAi-Independent Heterochromatin Nucleation by the Stress-Activated ATF/CREB Family Proteins
DNA near centromeres of yeast can be silenced by two stress-related transcription factors, independent of RNA-related silencing.
- Postnatal Refinement of Peripheral Olfactory Projections
Normal maturation of the sense of smell requires that mice experience various odors during a critical period of development.
- Regulation of Dendritic Protein Synthesis by Miniature Synaptic Events
Low-level background synaptic events unexpectedly influence local protein synthesis in neuronal dendrites.
- Deficit in Attachment Behavior in Mice Lacking the µ-Opioid Receptor Gene
Mouse pups that lack a type of opioid receptor usually associated with pain and reward are less attached to their mothers than are normal pups.
- Robust Temporal Coding in the Trigeminal System
With each movement of a rat's whisker, corresponding neurons in the brain receive a stereotyped, precisely timed train of action potentials.
- Layer-Specific Somatosensory Cortical Activation During Active Tactile Discrimination
Brain activity elicited by passive movement of a rat's whiskers differs from that induced by the rat's own active use of whiskers in exploring its environment.
