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Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone

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Science  30 Jul 2004:
Vol. 305, Issue 5684, pp. 683-686
DOI: 10.1126/science.1099736

Article Information

vol. 305 no. 5684 683-686

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Print ISSN: 
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History: 
  • Received for publication April 29, 2004
  • Accepted for publication July 7, 2004
  • .

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Author Information

  1. Pamela A. Williams1,
  2. Jose Cosme1,
  3. Dijana Matak Vinković1,
  4. Alison Ward1,*,
  5. Hayley C. Angove1,
  6. Philip J. Day1,
  7. Clemens Vonrhein2,
  8. Ian J. Tickle1,
  9. Harren Jhoti1,
  1. 1 Astex Technology, 436 Cambridge Science Park, Milton Road, Cambridge, CB4 0QA, UK.
  2. 2 Global Phasing Ltd., Sheraton House, Castle Park, Cambridge, CB3 0AX, UK.
  1. To whom correspondence should be addressed. E-mail: h.jhoti{at}astex-technology.com
  • * Present address: AstraZeneca, Research and Development, Charnwood, Bakewell Road, Loughborough, LE11 5RH, UK.

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