Report

Small Interfering RNA-Induced Transcriptional Gene Silencing in Human Cells

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Science  27 Aug 2004:
Vol. 305, Issue 5688, pp. 1289-1292
DOI: 10.1126/science.1101372

Article Information

vol. 305 no. 5688 1289-1292

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History: 
  • Received for publication June 14, 2004
  • Accepted for publication July 26, 2004

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Author Information

  1. Kevin V. Morris1,*,,
  2. Simon W.-L. Chan2,
  3. Steven E. Jacobsen2,3,
  4. David J. Looney1,4
  1. 1 Department of Medicine 0678, Stein Clinical Research Building, Room 302, University of California–San Diego, La Jolla, CA 92093–0678, USA.
  2. 2 Department of Molecular, Cell, and Developmental Biology, University of California–Los Angeles, Los Angeles, CA 90095–1606, USA.
  3. 3 Molecular Biology Institute, University of California–Los Angeles, Los Angeles, CA 90095–1606, USA.
  4. 4 VA San Diego Healthcare System, Infectious Diseases, San Diego, CA 92161, USA.
  1. To whom correspondence should be addressed. E-mail: kmorris{at}coh.org
  • Note added in proof: After this work was submitted, Fukugawa et al. showed that Dicer-defective chicken cells have heterochromatin defects at centromeres, possibly implicating siRNA in centromeric silencing (31).

  • * Present address: Division of Molecular Biology, Beckman Research Institute, 1450 East Duarte Road, Duarte, CA 91010–3011, USA.

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