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Src Mediates a Switch from Microtubule- to Actin-Based Motility of Vaccinia Virus

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Science  01 Oct 2004:
Vol. 306, Issue 5693, pp. 124-129
DOI: 10.1126/science.1101509

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Abstract

The cascade of events that leads to vaccinia-induced actin polymerization requires Src-dependent tyrosine phosphorylation of the viral membrane protein A36R. We found that a localized outside-in signaling cascade induced by the viral membrane protein B5R is required to potently activate Src and induce A36R phosphorylation at the plasma membrane. In addition, Src-mediated phosphorylation of A36R regulated the ability of virus particles to recruit and release conventional kinesin. Thus, Src activity regulates the transition between cytoplasmic microtubule transport and actin-based motility at the plasma membrane.

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