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Defective Telomere Lagging Strand Synthesis in Cells Lacking WRN Helicase Activity

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Science  10 Dec 2004:
Vol. 306, Issue 5703, pp. 1951-1953
DOI: 10.1126/science.1103619

Article Information

vol. 306 no. 5703 1951-1953

DOI: 
https://doi.org/10.1126/science.1103619
PubMed: 
15591207
Published By: 
American Association for the Advancement of Science
Print ISSN: 
0036-8075
Online ISSN: 
1095-9203
History: 
  • Received for publication August 3, 2004
  • Accepted for publication October 21, 2004
  • .
Copyright & Usage: 
American Association for the Advancement of Science

Author Information

  1. Laure Crabbe,
  2. Ramiro E. Verdun,
  3. Candy I. Haggblom,
  4. Jan Karlseder*
  1. The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
  1. ↵* To whom correspondence should be addressed. E-mail: Karlseder{at}salk.edu

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  • Defective Telomere Lagging Strand Synthesis in Cells Lacking WRN Helicase Activity

    By Laure Crabbe, Ramiro E. Verdun, Candy I. Haggblom, Jan Karlseder

    Science : 1951-1953

    The gene defective in Werner syndrome, a premature aging disease, is normally responsible for the proper replication of DNA at the ends of chromosomes.

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