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Nod2 Mutation in Crohn's Disease Potentiates NF-κB Activity and IL-1ß Processing

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Science  04 Feb 2005:
Vol. 307, Issue 5710, pp. 734-738
DOI: 10.1126/science.1103685

Article Information

vol. 307 no. 5710 734-738

PubMed: 
Print ISSN: 
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History: 
  • Received for publication August 5, 2004
  • Accepted for publication December 8, 2004
  • .

Author Information

  1. Shin Maeda1,
  2. Li-Chung Hsu1,*,
  3. Hongjun Liu1,*,
  4. Laurie A. Bankston1,3,
  5. Mitsutoshi Iimura2,
  6. Martin F. Kagnoff2,
  7. Lars Eckmann2,
  8. Michael Karin1,
  1. 1 Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093–0723, USA.
  2. 2 Laboratory of Mucosal Immunology, Departments of Medicine and Pediatrics, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093–0723, USA.
  3. 3 Program on Cell Adhesion, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
  1. To whom correspondence should be addressed. E-mail: karinoffice{at}ucsd.edu
  • * These authors contributed equally to this work.

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