Thymic Regulation--Hidden in Plain Sight

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Science  11 Feb 2005:
Vol. 307, Issue 5711, pp. 858-859
DOI: 10.1126/science.1109501

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The thymus is the nursery where T cell precursors mature into T cells of theandlineages. In a Perspective, Rothenberg discusses intriguing findings that reveal a new level of regulation in the thymus ( Silva-Santos et al.). Apparently, double-positive T cells that are destined to mature intoT cells directly regulate the development of theT-cell lineage through the production of lymphotoxin and the action of a transcription factor called RORt.