15 April 2005
Vol 308, Issue 5720

About The Cover

Cover image expansion

COVER A human retina (center) with complement factor H, a regulator in innate immunity, shown in red. As described on page 385, individuals with a variant form of this factor have an increased risk of age-related macular degeneration (AMD), as shown in photos at left and right. Also shown in the center retina, from a deceased person without AMD, are cell nuclei (blue), lipofuscin granules (yellow) in retinal pigment epithelium, and elastin (green) in Bruch's membrane and large blood vessels. [Images: J. Tsai; F. Ferris and E. Chew; C. Zeiss; background image: Jupiter Images]