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H2S Induces a Suspended Animation–Like State in Mice

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Science  22 Apr 2005:
Vol. 308, Issue 5721, pp. 518
DOI: 10.1126/science.1108581

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  • Reflections on the purpose of oxygen consumption

    I found the article by Blackstone and colleagues intriguing (1). It made me question how much of the oxygen consumed, by a mouse at "rest," is actually coupled to ATP regeneration and hence how relevant it might be to draw parallels to humans. Indeed, this question reflects the dilemma of how useful murine models of metabolism may be for the study of human metabolic disease if "regulation" can be so fundamentally geared to...

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    Competing Interests: None declared.
  • Toxicant-induced regulated hypothermia

    I found the paper describing suspended animation in the mouse induced by exposure to hydrogen sulfide to be interesting. However, I was surprised that the authors did not acknowledge the extensive data base on toxicant-induced hypothermia in rodents (1-4). The term “regulated hypothermia” was coined over 18 years ago to describe the nature of the thermoregulatory response of rodents exposed to a toxicant or drug that in...

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    Competing Interests: None declared.
  • Hydrogen sulfide is also highly toxic

    Having read the interesting article on the induction of an inactive state by hydrogen sulfide in mice, I would like to remind readers that the gas is also highly toxic because it is an inhibitor of the mitocondrial cytochrome oxidase, thereby causing histotoxic hypoxia resulting in death. Even nonlethal exposure is associated with marked mitochondrial effects in brain and in other highly oxygen-dependent organs (1). Fatal...

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    Competing Interests: None declared.

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