PerspectiveCell Biology

Lessons in Rational Drug Design for Protein Kinases

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Science  27 May 2005:
Vol. 308, Issue 5726, pp. 1266-1267
DOI: 10.1126/science.1113707

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A Holy Grail of marrying bioinformatics with structural biology is the design of drugs that precisely affect specific cellular targets. Ahn and Resing discuss in their Perspective how combining sequence and structural analysis of the catalytic site of protein kinases allowed one group to rationally design molecules that selectively block p90 ribosomal S6 kinase enzymatic activity in cells.