The Anti-Aging Sweepstakes: Catalase Runs for the ROSes

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Science  24 Jun 2005:
Vol. 308, Issue 5730, pp. 1875-1876
DOI: 10.1126/science.1114393

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In a Perspective, Miller discusses new data on transgenic mice showing that better antioxidative defenses can boost life span in a mammal. Other long-lived mutants, in contrast, resist multiple forms of cell injury, and mutants with low oxidation resistance can nonetheless retain normal longevity. Comparisons among long- and short-lived species could reveal new links between stress resistance and aging.