Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria

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Science  24 Jun 2005:
Vol. 308, Issue 5730, pp. 1909-1911
DOI: 10.1126/science.1106653

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  • Role of Catalase in Life Span Extension

    The work by Schriner and colleagues is an important advance in understanding the free radical theory of aging and its implications for healthy aging and longevity (1). These investigators created transgenic mice that overexpress human catalase localized to peroxisomes, nucleus, and mitochondria, and studied the effects of aging from birth to death in these transgenic mouse lines. Interestingly, but not surprisingly, t...

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    Competing Interests: None declared.
  • Catalase versus Glutathione Peroxidase

    The paper by Schriner et al. adds considerable weight to the growing body of scientific evidence on the role of oxygen-derived free radicals in aging, notably in the cardiac mitochondrion. However, it is noteworthy that although the authors attribute the significantly increased life-span to the overexpression of catalase (CAT) in heart mitochondria in transgenic mice (MCAT) as compared with wild-type (WT) mice, they fail...

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    Competing Interests: None declared.