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Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function

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Science  15 Jul 2005:
Vol. 309, Issue 5733, pp. 476-481
DOI: 10.1126/science.1113694

Article Information

vol. 309 no. 5733 476-481

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Print ISSN: 
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History: 
  • Received for publication April 18, 2005
  • Accepted for publication May 27, 2005

Author Information

  1. K. SantaCruz1,*,
  2. J. Lewis5,*,
  3. T. Spires6,*,
  4. J. Paulson2,
  5. L. Kotilinek2,
  6. M. Ingelsson6,
  7. A. Guimaraes2,
  8. M. DeTure5,
  9. M. Ramsden2,
  10. E. McGowan5,
  11. C. Forster1,
  12. M. Yue5,
  13. J. Orne6,
  14. C. Janus5,
  15. A. Mariash2,
  16. M. Kuskowski7,
  17. B. Hyman6,
  18. M. Hutton5,
  19. K. H. Ashe2,3,4,7,
  1. 1 Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
  2. 2 Department of Neurology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
  3. 3 Department of Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
  4. 4 Graduate Program in Neuroscience, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
  5. 5 Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA.
  6. 6 Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA.
  7. 7 Geriatric Research, Education, and Clinical Center (GRECC), Minneapolis VA Hospital, Minneapolis, MN 55417, USA.
  1. To whom correspondence should be addressed. E-mail: hsiao005{at}umn.edu
  • * These authors contributed equally to this work.

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