22 July 2005
Vol 309, Issue 5734

About The Cover

Cover image expansion

COVER A surface representation of human Toll-like receptor 3, derived from the x-ray crystal structure and shown on a cell membrane. The glycosylated Toll-like receptor dimer (green with pink sugars) recognizes double-stranded RNA (orange) from microbial pathogens such as viruses (lavender). Binding of the RNA to the receptor activates the innate immune system. The structure is described on page 581. [Image: J. Choe, M. Pique, and I. A. Wilson]