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The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

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Science  09 Dec 2005:
Vol. 310, Issue 5754, pp. 1642-1646
DOI: 10.1126/science.1120781

Article Information

vol. 310 no. 5754 1642-1646

PubMed: 
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History: 
  • Received for publication September 30, 2005
  • Accepted for publication November 9, 2005
  • .

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Author Information

  1. Reuben J. Shaw1,2,*,,
  2. Katja A. Lamia1,2,
  3. Debbie Vasquez2,
  4. Seung-Hoi Koo3,4,
  5. Nabeel Bardeesy5,
  6. Ronald A. DePinho6,
  7. Marc Montminy3,
  8. Lewis C. Cantley1,2
  1. 1 Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  2. 2 Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
  3. 3 Peptide Biology Laboratories, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
  4. 4 Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon 440-746, Korea.
  5. 5 Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
  6. 6 Center for Applied Cancer Science and Department of Medical Oncology, Dana Farber Cancer Institute and Departments of Medicine and Genetics, Harvard Medical School, Boston, MA 02115, USA.
  1. * To whom correspondence should be addressed. E-mail: shaw{at}salk.edu
  • Present address: Molecular and Cell Biology Laboratories, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037–1002, USA.

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