Using Silver to Sugarcoat DNA

See allHide authors and affiliations

Science  27 Jan 2006:
Vol. 311, Issue 5760, pp. 437
DOI: 10.1126/science.311.5760.437c

One strategy for wiring nanodevices together is to make the desired connections with DNA strands, which can then be metallized. For molecular electronics, it would be useful to create metal-free gaps in these wires, and for the chemical reduction of silver with aldehydemodified DNA, such gaps can be created by binding large proteins to the DNA, which then act as a resist.

Burley et al. describe an alternative approach in which modified DNA molecules are synthesized using Pwo polymerase with modified dTTPs bearing acetylenic groups. A protected aldehyde, in the form of a galactose that has been modified with an azide group, can then react with the acetylenic side chains via “click” chemistry. Treatment of a 318-base pair modified DNA with silver salt solution (Tollens' reagent) and then with a developer solution deposited silver nanoparticles on the DNA, which was confirmed by atomic force microscopy. — PDS

J. Am. Chem. Soc. 10.1021/ja055517v (2006).

Stay Connected to Science

Navigate This Article