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Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome

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Science  07 Apr 2006:
Vol. 312, Issue 5770, pp. 117-121
DOI: 10.1126/science.1124287

Article Information

vol. 312 no. 5770 117-121

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication December 23, 2005
  • Accepted for publication March 2, 2006
  • .

Author Information

  1. Jennifer P. Habashi1,*,
  2. Daniel P. Judge2,*,
  3. Tammy M. Holm1,
  4. Ronald D. Cohn1,
  5. Bart L. Loeys1,
  6. Timothy K. Cooper1,3,
  7. Loretha Myers1,
  8. Erin C. Klein1,
  9. Guosheng Liu3,
  10. Carla Calvi2,
  11. Megan Podowski2,
  12. Enid R. Neptune2,
  13. Marc K. Halushka4,
  14. Djahida Bedja3,
  15. Kathleen Gabrielson3,
  16. Daniel B. Rifkin5,
  17. Luca Carta6,
  18. Francesco Ramirez6,
  19. David L. Huso3,
  20. Harry C. Dietz1,2,
  1. 1 Howard Hughes Medical Institute and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  2. 2 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  3. 3 Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  4. 4 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  5. 5 Departments of Cell Biology and Medicine, New York University School of Medicine, New York, NY 10016, USA.
  6. 6 Child Health Institute of New Jersey, University of Medicine and Dentistry of New Jersey–Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA.
  1. To whom correspondence should be addressed. E-mail: hdietz{at}jhmi.edu
  • * These authors contributed equally to this work.

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