Discriminating Microbe from Self Suffers a Double Toll

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Science  16 Jun 2006:
Vol. 312, Issue 5780, pp. 1606-1608
DOI: 10.1126/science.1129797

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The autoimmune disease lupus is caused by immune cells that secrete antibodies to the patient's own antigens. A mouse version of the disease reveals two genes that lead to this disregulation.