Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes

Richard A. Morgan; Mark E. Dudley; John R. Wunderlich; Marybeth S. Hughes; James C. Yang; Richard M. Sherry; Richard E. Royal; Suzanne L. Topalian; Udai S. Kammula; Nicholas P. Restifo; Zhili Zheng; Azam Nahvi; Christiaan R. de Vries; Linda J. Rogers-Freezer; Sharon A. Mavroukakis; Steven A. Rosenberg

doi:10.1126/science.1129003

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Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes

Richard A. Morgan,
Mark E. Dudley,
John R. Wunderlich,
Marybeth S. Hughes,
James C. Yang,
Richard M. Sherry,
Richard E. Royal,
Suzanne L. Topalian,
Udai S. Kammula,
Nicholas P. Restifo,
Zhili Zheng,
Azam Nahvi,
Christiaan R. de Vries,
Linda J. Rogers-Freezer,
Sharon A. Mavroukakis,
Steven A. Rosenberg*

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

↵* To whom correspondence should be addressed. E-mail: SAR{at}mail.nih.gov

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Science 06 Oct 2006:
Vol. 314, Issue 5796, pp. 126-129
DOI: 10.1126/science.1129003

Richard A. Morgan

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

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Mark E. Dudley

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

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John R. Wunderlich

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

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Marybeth S. Hughes

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

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James C. Yang

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

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Richard M. Sherry

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

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Richard E. Royal

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

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Suzanne L. Topalian

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

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Udai S. Kammula

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

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Nicholas P. Restifo

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

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Zhili Zheng

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

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Azam Nahvi

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

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Christiaan R. de Vries

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

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Linda J. Rogers-Freezer

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

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Sharon A. Mavroukakis

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

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Steven A. Rosenberg

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

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For correspondence: SAR@mail.nih.gov

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Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes

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