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Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

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Science  06 Oct 2006:
Vol. 314, Issue 5796, pp. 130-133
DOI: 10.1126/science.1134108

Article Information

vol. 314 no. 5796 130-133

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication August 21, 2006
  • Accepted for publication September 8, 2006
  • .

Author Information

  1. Manuela Neumann1,11,*,
  2. Deepak M. Sampathu1,*,
  3. Linda K. Kwong1,*,
  4. Adam C. Truax1,
  5. Matthew C. Micsenyi1,
  6. Thomas T. Chou2,
  7. Jennifer Bruce1,
  8. Theresa Schuck1,
  9. Murray Grossman3,4,
  10. Christopher M. Clark3,4,
  11. Leo F. McCluskey3,
  12. Bruce L. Miller6,
  13. Eliezer Masliah7,
  14. Ian R. Mackenzie8,
  15. Howard Feldman9,
  16. Wolfgang Feiden10,
  17. Hans A. Kretzschmar11,
  18. John Q. Trojanowski1,4,5,
  19. Virginia M.-Y. Lee1,4,5,
  1. 1 Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  2. 2 Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  3. 3 Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  4. 4 Alzheimer's Disease Core Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  5. 5 Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  6. 6 Department of Neurology, University of California at San Francisco, CA 94117, USA.
  7. 7 Department of Neurosciences, University of California San Diego, School of Medicine, La Jolla, CA 92093, USA.
  8. 8 Department of Pathology, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada.
  9. 9 Division of Neurology, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada.
  10. 10 Institute for Neuropathology, University of the Saarland, 66421 Homburg, Germany.
  11. 11 Center for Neuropathology and Prion Research, Ludwig-Maximilians University, 81377 Munich, Germany.
  1. To whom correspondence should be addressed. E-mail: vmylee{at}mail.med.upenn.edu
  • * These authors contributed equally to this work.

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