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A "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity

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Science  26 Jan 2007:
Vol. 315, Issue 5811, pp. 525-528
DOI: 10.1126/science.1135308

Article Information

vol. 315 no. 5811 525-528

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Print ISSN: 
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History: 
  • Received for publication September 19, 2006
  • Accepted for publication November 28, 2006

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Author Information

  1. Chava Kimchi-Sarfaty*,,
  2. Jung Mi Oh,
  3. In-Wha Kim,
  4. Zuben E. Sauna,
  5. Anna Maria Calcagno,
  6. Suresh V. Ambudkar,
  7. Michael M. Gottesman
  1. Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  1. To whom correspondence should be addressed. E-mail: mgottesman{at}nih.gov (M.M.G.); jmoh{at}snu.ac.kr (J.M.O.); kimchi{at}cber.fda.gov (C.K.-S.)
  • * Present address: Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Room 316, Bethesda, MD 20892, USA.

  • Present address: College of Pharmacy, Seoul National University, Seoul 151-742, South Korea.

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