Report

A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

See allHide authors and affiliations

Science  11 May 2007:
Vol. 316, Issue 5826, pp. 889-894
DOI: 10.1126/science.1141634

Article Information

vol. 316 no. 5826 889-894

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication February 22, 2007
  • Accepted for publication April 6, 2007
  • .

Article Versions

Other Contributors: 
  • The Wellcome Trust Case Control Consortium

Author Information

  1. Timothy M. Frayling1,2,*,
  2. Nicholas J. Timpson3,4,*,
  3. Michael N. Weedon1,2,*,
  4. Eleftheria Zeggini3,5,*,
  5. Rachel M. Freathy1,2,
  6. Cecilia M. Lindgren3,5,
  7. John R. B. Perry1,2,
  8. Katherine S. Elliott3,
  9. Hana Lango1,2,
  10. Nigel W. Rayner3,5,
  11. Beverley Shields2,
  12. Lorna W. Harries2,
  13. Jeffrey C. Barrett3,
  14. Sian Ellard2,6,
  15. Christopher J. Groves5,
  16. Bridget Knight2,
  17. Ann-Marie Patch2,6,
  18. Andrew R. Ness7,
  19. Shah Ebrahim8,
  20. Debbie A. Lawlor9,
  21. Susan M. Ring9,
  22. Yoav Ben-Shlomo9,
  23. Marjo-Riitta Jarvelin10,11,
  24. Ulla Sovio10,11,
  25. Amanda J. Bennett5,
  26. David Melzer1,12,
  27. Luigi Ferrucci13,
  28. Ruth J. F. Loos14,
  29. Inês Barroso15,
  30. Nicholas J. Wareham14,
  31. Fredrik Karpe5,
  32. Katharine R. Owen5,
  33. Lon R. Cardon3,
  34. Mark Walker16,
  35. Graham A. Hitman17,
  36. Colin N. A. Palmer18,
  37. Alex S. F. Doney19,
  38. Andrew D. Morris19,
  39. George Davey Smith4,
  40. The Wellcome Trust Case Control Consortium,
  41. Andrew T. Hattersley1,2,§,
  42. Mark I. McCarthy3,5,
  1. 1 Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, UK.
  2. 2 Diabetes Genetics, Institute of Biomedical and Clinical Science, Peninsula Medical School, Barrack Road, Exeter, UK.
  3. 3 Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK.
  4. 4 MRC Centre for Causal Analyses in Translational Epidemiology, Bristol University, Canynge Hall, Whiteladies Road, Bristol, UK.
  5. 5 Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK.
  6. 6 Molecular Genetics Laboratory, Royal Devon and Exeter National Health Service Foundation Trust, Old Pathology Building, Barrack Road, Exeter, UK.
  7. 7 Department of Oral and Dental Science, University of Bristol Dental School, Lower Maudlin Street, Bristol, UK.
  8. 8 Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.
  9. 9 Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, UK.
  10. 10 Department of Epidemiology and Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.
  11. 11 Department of Public Health Science and General Practice, Fin-90014, University of Oulu, Finland.
  12. 12 Epidemiology and Public Health Group, Peninsula Medical School, Barrack Road, Exeter, UK.
  13. 13 Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
  14. 14 Medical Research Council Epidemiology Unit, Strangeways Research Laboratories, Cambridge, UK.
  15. 15 Metabolic Disease Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
  16. 16 Diabetes Research Group, School of Clinical Medical Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, UK.
  17. 17 Centre for Diabetes and Metabolic Medicine, Barts and The London, Royal London Hospital, Whitechapel, London, UK.
  18. 18 Population Pharmacogenetics Group, Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
  19. 19 Diabetes Research Group, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
  1. § To whom correspondence should be addressed. E-mail: Andrew.Hattersley{at}pms.ac.uk
  • * These authors contributed equally to this work.

  • Membership of the Wellcome Trust Case Control Consortium is listed in the Supporting Online Material.

  • These authors contributed equally to this work.

Altmetric

Article usage

Article usage: April 2007 to November 2019

AbstractFullPdf
Apr 2007645103568
May 2007441514942733
Jun 2007889674787
Jul 2007539506504
Aug 2007356413365
Sep 2007442381321
Oct 2007508469391
Nov 2007702522485
Dec 2007449285267
Jan 2008480412342
Feb 2008490300259
Mar 2008617346297
Apr 2008563272257
May 2008546252235
Jun 2008506243252
Jul 2008447251220
Aug 2008321227162
Sep 2008690271261
Oct 2008599294264
Nov 2008710311278
Dec 2008628250236
Jan 2009661258335
Feb 2009772263243
Mar 2009863246229
Apr 2009730217199
May 2009562177171
Jun 2009383136113
Jul 200936196101
Aug 200937610588
Sep 2009509124114
Oct 2009644145152
Nov 2009839189153
Dec 2009556139126
Jan 2010599119114
Feb 2010597162146
Mar 2010788184186
Apr 20101021161170
May 2010667160171
Jun 2010453102108
Jul 20104319986
Aug 20104174484
Sep 201048047112
Oct 201075383151
Nov 201086693134
Dec 201066687123
Jan 201166666103
Feb 2011708100135
Mar 2011902129161
Apr 2011741105120
May 20116459796
Jun 20115156095
Jul 20114475287
Aug 20113735284
Sep 201163483120
Oct 2011871121128
Nov 2011924133162
Dec 20116079786
Jan 20125376187
Feb 201269875134
Mar 2012840115145
Apr 201279274107
May 201258790106
Jun 20124176566
Jul 20123578267
Aug 20123448079
Sep 20124497058
Oct 2012801120123
Nov 2012785169109
Dec 20125456471
Jan 2013724106106
Feb 201358011773
Mar 201372910591
Apr 201370811196
May 201355812898
Jun 20133806854
Jul 2013227010896
Aug 20135546963
Sep 20136829890
Oct 2013173315193
Nov 2013917223107
Dec 20136167159
Jan 20144547858
Feb 20145527663
Mar 20141039184158
Apr 2014894196127
May 201472414696
Jun 20144467867
Jul 20144145850
Aug 20143225840
Sep 20145679570
Oct 2014821127126
Nov 2014804103127
Dec 201462212487
Jan 201565210384
Feb 201568912493
Mar 201586211580
Apr 201578419287
May 20156037951
Jun 20153926950
Jul 20153855248
Aug 20156207558
Sep 201575712674
Oct 201581115383
Nov 201593821698
Dec 20156297757
Jan 20165946691
Feb 20166289666
Mar 20166898265
Apr 20167689679
May 20167007481
Jun 20165274254
Jul 20164793538
Aug 20166103961
Sep 20167385772
Oct 20167498069
Nov 20168418097
Dec 20165824950
Jan 20177458770
Feb 20179377461
Mar 201712609776
Apr 201711066460
May 20179795445
Jun 20176723349
Jul 20176624655
Aug 20176425163
Sep 20176396265
Oct 20177406373
Nov 201775891132
Dec 20176925868
Jan 20189824555
Feb 201820585474
Mar 201816837491
Apr 201826535779
May 201825544964
Jun 201822174144
Jul 201824252250
Aug 201818107362
Sep 201815617988
Oct 20181154102115
Nov 2018710192134
Dec 20181947771
Jan 201932011161
Feb 201926511068
Mar 201930615851
Apr 201926416883
May 201926513068
Jun 20192268357
Jul 20192219360
Aug 20192509064
Sep 201925411247
Oct 201925118061
Nov 2019913316