Report

MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling

See allHide authors and affiliations

Science  18 May 2007:
Vol. 316, Issue 5827, pp. 1039-1043
DOI: 10.1126/science.1141478

Article Information

vol. 316 no. 5827 1039-1043

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication February 20, 2007
  • Accepted for publication April 11, 2007
  • .

Article Versions

Author Information

  1. Jeffrey A. Engelman1,2,3,
  2. Kreshnik Zejnullahu4,5,
  3. Tetsuya Mitsudomi6,
  4. Youngchul Song2,3,
  5. Courtney Hyland7,
  6. Joon Oh Park4,5,
  7. Neal Lindeman7,
  8. Christopher-Michael Gale3,
  9. Xiaojun Zhao5,
  10. James Christensen8,
  11. Takayuki Kosaka6,
  12. Alison J. Holmes4,5,
  13. Andrew M. Rogers5,
  14. Federico Cappuzzo9,
  15. Tony Mok10,
  16. Charles Lee7,
  17. Bruce E. Johnson4,5,
  18. Lewis C. Cantley2,3,
  19. Pasi A. Jänne4,5,*
  1. 1 Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
  2. 2 Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  3. 3 Department of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
  4. 4 Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  5. 5 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  6. 6 Department of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya 464-8681, Japan.
  7. 7 Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.
  8. 8 Pfizer Global Research and Development, Department of Research Pharmacology, La Jolla Laboratories, La Jolla, CA 92121, USA.
  9. 9 Istituto Clinico Humanitas, Department on Hematology-Oncology, Rozzano 20089, Italy.
  10. 10 Department of Clinical Oncology, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
  1. * To whom correspondence should be addressed. E-mail: pjanne{at}partners.org

Altmetric

Article usage

Article usage: April 2007 to September 2019

AbstractFullPdf
Apr 20077360438
May 2007311811502664
Jun 20076779911096
Jul 2007230625594
Aug 2007138457449
Sep 2007109399361
Oct 2007418575603
Nov 2007225515447
Dec 2007268324330
Jan 2008206447379
Feb 2008137293252
Mar 2008241337307
Apr 2008159289248
May 2008172300243
Jun 2008195344245
Jul 2008204272211
Aug 2008172204164
Sep 2008244242233
Oct 2008277270238
Nov 2008219250199
Dec 2008149208160
Jan 2009230263200
Feb 2009179212162
Mar 2009180213199
Apr 2009146194181
May 2009166233204
Jun 2009147150127
Jul 2009144162164
Aug 2009127135148
Sep 2009179188207
Oct 2009244152155
Nov 2009209204174
Dec 2009190138125
Jan 2010213244210
Feb 2010228172154
Mar 2010265212202
Apr 2010173165158
May 2010264220213
Jun 2010253176167
Jul 2010231208160
Aug 201037275177
Sep 201039197173
Oct 201052097240
Nov 201050298188
Dec 201046490162
Jan 201144063183
Feb 2011489114222
Mar 2011574102236
Apr 2011625105178
May 201158986197
Jun 201153983178
Jul 201158593160
Aug 2011610117204
Sep 2011701121214
Oct 2011699107236
Nov 2011703117236
Dec 201142196152
Jan 2012596123230
Feb 2012684163224
Mar 2012600100217
Apr 201258497205
May 2012681109196
Jun 2012412120143
Jul 2012404164153
Aug 2012421158167
Sep 2012505169151
Oct 2012687201179
Nov 2012495145128
Dec 2012510128148
Jan 2013497151152
Feb 2013514152166
Mar 2013638185174
Apr 2013494174132
May 2013389159139
Jun 2013309147130
Jul 2013502180171
Aug 2013412158139
Sep 2013636213178
Oct 2013560144148
Nov 2013589199177
Dec 2013471168152
Jan 2014511180157
Feb 2014461125121
Mar 2014521159161
Apr 2014520168154
May 2014622153405
Jun 2014430132117
Jul 2014355129127
Aug 2014344116119
Sep 2014420157100
Oct 2014446168132
Nov 2014434139119
Dec 2014367143128
Jan 2015393129122
Feb 2015334179111
Mar 2015362168129
Apr 2015257152101
May 2015351161114
Jun 2015375185130
Jul 2015276151125
Aug 201532311883
Sep 2015430151105
Oct 2015345194101
Nov 2015385244131
Dec 201535414199
Jan 20164105953
Feb 2016268119100
Mar 2016669150152
Apr 20161116186135
May 20161762142109
Jun 20161251127131
Jul 201621175090
Aug 2016175975102
Sep 2016117260113
Oct 2016118396140
Nov 2016102661115
Dec 20168367397
Jan 20176345793
Feb 201750181113
Mar 201760478119
Apr 20174707197
May 201746467134
Jun 20173766070
Jul 20173787698
Aug 201783146483
Sep 2017541555692
Oct 2017478516887
Nov 2017379395999
Dec 2017742856474
Jan 2018601717090
Feb 2018550677391
Mar 20184215883137
Apr 2018400276075
May 20183657177115
Jun 2018341155474
Jul 2018384137374
Aug 20181773813357
Sep 20182446313872
Oct 20183170614073
Nov 2018841022366
Dec 201825610347
Jan 2019291165121
Feb 201927115480
Mar 201922518361
Apr 201923715480
May 201929619484
Jun 201916518071
Jul 201922213966
Aug 201939712464
Sep 2019925834