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Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes

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Science  01 Jun 2007:
Vol. 316, Issue 5829, pp. 1336-1341
DOI: 10.1126/science.1142364

Article Information

vol. 316 no. 5829 1336-1341

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication March 9, 2007
  • Accepted for publication April 20, 2007
  • .

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Other Contributors: 
  • The Wellcome Trust Case Control Consortium (WTCCC)

Author Information

  1. Eleftheria Zeggini1,2,*,
  2. Michael N. Weedon3,4,*,
  3. Cecilia M. Lindgren1,2,*,
  4. Timothy M. Frayling3,4,*,
  5. Katherine S. Elliott2,
  6. Hana Lango3,4,
  7. Nicholas J. Timpson2,5,
  8. John R. B. Perry3,4,
  9. Nigel W. Rayner1,2,
  10. Rachel M. Freathy3,4,
  11. Jeffrey C. Barrett2,
  12. Beverley Shields4,
  13. Andrew P. Morris2,
  14. Sian Ellard4,6,
  15. Christopher J. Groves1,
  16. Lorna W. Harries4,
  17. Jonathan L. Marchini7,
  18. Katharine R. Owen1,
  19. Beatrice Knight4,
  20. Lon R. Cardon2,
  21. Mark Walker8,
  22. Graham A. Hitman9,
  23. Andrew D. Morris10,
  24. Alex S. F. Doney10,
  25. The Wellcome Trust Case Control Consortium (WTCCC),
  26. Mark I. McCarthy1,2,§,
  27. Andrew T. Hattersley3,4,
  1. 1 Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK.
  2. 2 The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX37BN, UK.
  3. 3 Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter EX1 2LU, UK.
  4. 4 Diabetes Genetics Group, Institute of Biomedical and Clinical Science, Peninsula Medical School, Barrack Road, Exeter EX2 5DW, UK.
  5. 5 Medical Research Council Centre for Causal Analyses in Translational Epidemiology, Bristol University, Canynge Hall, Whiteladies Rd, Bristol, BS2 8PR, UK.
  6. 6 The Molecular Genetics Laboratory, Royal Devon and Exeter NHS Foundation Trust, Old Pathology Building, Barrack Road, Exeter, EX2 5DW, UK.
  7. 7 Department of Statistics, University of Oxford, 1 South Parks Road, Oxford, OX1 3TG, UK.
  8. 8 Diabetes Research Group, School of Clinical Medical Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
  9. 9 Centre for Diabetes and Metabolic Medicine, Barts and The London, Royal London Hospital, Whitechapel, London, E1 1BB, UK.
  10. 10 Diabetes Research Group, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.
  1. § To whom correspondence should be addressed. E-mail: mark.mccarthy{at}drl.ox.ac.uk
  • * These authors contributed equally to this work.

  • Membership of the WTCCC is listed at the end of this paper.

  • These authors contributed equally to this work.

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