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A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1

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Science  17 Aug 2007:
Vol. 317, Issue 5840, pp. 944-947
DOI: 10.1126/science.1143767

Article Information

vol. 317 no. 5840 944-947

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History: 
  • Received for publication April 13, 2007
  • Accepted for publication July 2, 2007
  • .

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Author Information

  1. Jacques Fellay1,
  2. Kevin V. Shianna2,*,
  3. Dongliang Ge1,*,
  4. Sara Colombo3,*,
  5. Bruno Ledergerber4,*,
  6. Mike Weale1,*,
  7. Kunlin Zhang3,
  8. Curtis Gumbs1,
  9. Antonella Castagna5,
  10. Andrea Cossarizza6,
  11. Alessandro Cozzi-Lepri7,
  12. Andrea De Luca8,
  13. Philippa Easterbrook9,
  14. Patrick Francioli10,
  15. Simon Mallal11,
  16. Javier Martinez-Picado12,
  17. José M. Miro13,
  18. Niels Obel14,
  19. Jason P. Smith2,
  20. Josiane Wyniger3,
  21. Patrick Descombes15,
  22. Stylianos E. Antonarakis16,
  23. Norman L. Letvin17,
  24. Andrew J. McMichael18,
  25. Barton F. Haynes19,
  26. Amalio Telenti3,,
  27. David B. Goldstein1,
  1. 1 Center for Population Genomics and Pharmacogenetics, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA.
  2. 2 Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA.
  3. 3 Institute of Microbiology, University Hospital Center; and University of Lausanne, 1011 Lausanne, Switzerland.
  4. 4 Division of Infectious Diseases, University Hospital, 8091 Zürich, Switzerland.
  5. 5 Clinic of Infectious Diseases, Istituto di Ricovero e Cura a Carattere Scientifico, San Raffaele Hospital, 20127 Milan, Italy.
  6. 6 Department of Biomedical Sciences, Section of General Pathology, University of Modena and Reggio Emilia, School of Medicine, 41100 Modena, Italy.
  7. 7 Department of Primary Care and Population Sciences, Royal Free and University College Medical School, University College London, London NW3 2PF, UK.
  8. 8 Institute of Clinical Infectious Diseases, Catholic University of the Sacred Heart, 00168 Rome, Italy.
  9. 9 Academic Department of HIV and Genitourinary Medicine, Kings College London, at Guy's, King's, and St. Thomas' Hospitals, London SE5 9RJ, UK.
  10. 10 Service of Infectious Diseases, Department of Medicine and Service of Hospital Preventive Medicine, University Hospital Center, 1011 Lausanne, Switzerland.
  11. 11 Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital; and Murdoch University, Perth, WA 6000, Australia.
  12. 12 irsiCaixa Foundation and Hospital Germans Trias i Pujol, 08916 Badalona, Spain; and Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain.
  13. 13 Hospital Clinic–Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, 08036 Barcelona, Spain.
  14. 14 Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark.
  15. 15 Genomics Platform, National Centre of Competence in Research “Frontiers in Genetics,” University of Geneva, 1211 Geneva, Switzerland.
  16. 16 Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, Switzerland.
  17. 17 Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  18. 18 Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK.
  19. 19 Duke Human Vaccine Institute, Duke University, Durham, NC 27710, USA.
  1. To whom correspondence should be addressed. E-mail: amalio.telenti{at}chuv.ch (A.T.); d.goldstein{at}duke.edu (D.B.G.)
  • * These authors contributed equally to this work.

  • On behalf of the Center for HIV/AIDS Vaccine Immunology (CHAVI) and the Euro-CHAVI consortia.

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