Leptin Regulates Striatal Regions and Human Eating Behavior

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Science  07 Sep 2007:
Vol. 317, Issue 5843, pp. 1355
DOI: 10.1126/science.1144599

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  • Response to R. Uher and I. C. Campbell

    R. Uher and I. A. Campbell are concerned about the generalizability of our findings, derived as they were from the study of very rare individuals with complete congenital leptin deficiency. Their comments illustrate a commonly held belief, which we believe to be largely false, that because certain human disorders are rare, they cannot valuably illuminate normal physiology. The great advantage of studying subjects in whom a horm...

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    Competing Interests: None declared.
  • Leptin Regulates Human Eating Behavior?

    The proposition by I. S. Farooqi et al. (Brevia, "Leptin regulates striatal regions and human eating behavior," 7 September 2007, p. 1355; Published online 9 August 2007) that leptin regulates striatal regions and human eating behaviour is of interest because it links a peripheral signal related to nutritional state with the brain mechanisms underpinning the motivational salience of food. However, we are concerned abou...

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    Competing Interests: None declared.

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