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Coactivation of Receptor Tyrosine Kinases Affects the Response of Tumor Cells to Targeted Therapies

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Science  12 Oct 2007:
Vol. 318, Issue 5848, pp. 287-290
DOI: 10.1126/science.1142946

Article Information

vol. 318 no. 5848 287-290

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication March 23, 2007
  • Accepted for publication August 31, 2007
  • .

Article Versions

Author Information

  1. Jayne M. Stommel1,
  2. Alec C. Kimmelman1,2,
  3. Haoqiang Ying1,
  4. Roustem Nabioullin3,
  5. Aditya H. Ponugoti3,
  6. Ruprecht Wiedemeyer1,
  7. Alexander H. Stegh1,
  8. James E. Bradner4,
  9. Keith L. Ligon1,5,
  10. Cameron Brennan6,
  11. Lynda Chin1,3,7,
  12. Ronald A. DePinho1,3,8,*
  1. 1 Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.
  2. 2 Harvard Radiation Oncology Program, Harvard Medical School, Boston, MA 02115, USA.
  3. 3 Center for Applied Cancer Science, Belfer Institute for Innovative Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  4. 4 Division of Hematologic Neoplasia, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.
  5. 5 Department of Pathology, Division of Neuropathology, Brigham and Women's Hospital, Boston, MA 02115, USA.
  6. 6 Departments of Neurosurgery, Memorial Sloan Kettering Cancer Center and Neurological Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA.
  7. 7 Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA,
  8. 8 Departments of Medicine and Genetics, Harvard Medical School, Boston, MA 02115, USA.
  1. * To whom correspondence should be addressed. E-mail: ron_depinho{at}dfci.harvard.edu

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