Research Article

Paired-End Mapping Reveals Extensive Structural Variation in the Human Genome

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Science  19 Oct 2007:
Vol. 318, Issue 5849, pp. 420-426
DOI: 10.1126/science.1149504

Article Information

vol. 318 no. 5849 420-426

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History: 
  • Received for publication August 21, 2007
  • Accepted for publication September 13, 2007
  • .

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Author Information

  1. Jan O. Korbel1,2,*,
  2. Alexander Eckehart Urban3,*,
  3. Jason P. Affourtit4,*,
  4. Brian Godwin4,
  5. Fabian Grubert5,
  6. Jan Fredrik Simons4,
  7. Philip M. Kim1,
  8. Dean Palejev5,
  9. Nicholas J. Carriero6,
  10. Lei Du4,
  11. Bruce E. Taillon4,
  12. Zhoutao Chen4,
  13. Andrea Tanzer7,8,9,
  14. A. C. Eugenia Saunders3,
  15. Jianxiang Chi10,
  16. Fengtang Yang10,
  17. Nigel P. Carter10,
  18. Matthew E. Hurles10,
  19. Sherman M. Weissman5,
  20. Timothy T. Harkins11,
  21. Mark B. Gerstein1,6,12,
  22. Michael Egholm4,,
  23. Michael Snyder1,3,
  1. 1 Molecular Biophysics and Biochemistry Department, Yale University, New Haven, CT 06520, USA.
  2. 2 European Molecular Biology Laboratory, 69117 Heidelberg, Germany.
  3. 3 Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA.
  4. 4 454 Life Sciences, A Roche Company, Branford, CT 06405, USA.
  5. 5 Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.
  6. 6 Department of Computer Science, Yale University, New Haven, CT 06520, USA.
  7. 7 Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520, USA.
  8. 8 Department of Computer Science, University of Leipzig, 04107 Leipzig, Germany.
  9. 9 Institute for Theoretical Chemistry, University of Vienna, 1090 Vienna, Austria.
  10. 10 The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
  11. 11 Roche Applied Science, Indianapolis, IN 46250, USA.
  12. 12 Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA.
  1. To whom correspondence should be addressed. E-mail: megholm{at}454.com (M.E.); michael.snyder{at}yale.edu (M.S.)
  • * These authors contributed equally to this work.

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