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The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase

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Science  30 Nov 2007:
Vol. 318, Issue 5855, pp. 1469-1472
DOI: 10.1126/science.1151710

Article Information

vol. 318 no. 5855 1469-1472

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History: 
  • Received for publication August 22, 2007
  • Accepted for publication October 30, 2007
  • .

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Author Information

  1. Thomas Gerken1,
  2. Christophe A. Girard2,*,
  3. Yi-Chun Loraine Tung3,*,
  4. Celia J. Webby1,,
  5. Vladimir Saudek3,,
  6. Kirsty S. Hewitson1,4,,
  7. Giles S. H. Yeo3,,
  8. Michael A. McDonough1,,
  9. Sharon Cunliffe4,,
  10. Luke A. McNeill1,4,,
  11. Juris Galvanovskis5,,
  12. Patrik Rorsman5,
  13. Peter Robins6,
  14. Xavier Prieur3,
  15. Anthony P. Coll3,
  16. Marcella Ma3,
  17. Zorica Jovanovic3,
  18. I. Sadaf Farooqi3,
  19. Barbara Sedgwick6,
  20. Inês Barroso7,
  21. Tomas Lindahl6,
  22. Chris P. Ponting8,,§,
  23. Frances M. Ashcroft2,,§,
  24. Stephen O'Rahilly3,§,
  25. Christopher J. Schofield1,,§
  1. 1 Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, Oxon OX1 3TA, UK.
  2. 2 Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, Oxon OX1 3PT, UK.
  3. 3 University of Cambridge, Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.
  4. 4 ReOx Ltd., Magdalen Centre, The Oxford Science Park, Oxford, Oxon OX4 4GA, UK.
  5. 5 Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, Oxon OX3 7LJ, UK.
  6. 6 Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK.
  7. 7 Metabolic Disease Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
  8. 8 MRC Functional Genetics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, Oxon OX1 3QX, UK.
  1. To whom correspondence should be addressed. E-mail: chris.ponting{at}dpag.ox.ac.uk (C.P.P.); frances.ashcroft{at}dpag.ox.ac.uk (F.M.A.); so104{at}medschl.cam.ac.uk (S.O.); christopher.schofield{at}chem.ox.ac.uk (C.J.S.)
  • * These authors contributed equally to this work.

  • These authors contributed equally to this work.

  • These authors contributed equally to this work.

  • § These authors contributed equally to this work.

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