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Structure of Gαq-p63RhoGEF-RhoA Complex Reveals a Pathway for the Activation of RhoA by GPCRs

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Science  21 Dec 2007:
Vol. 318, Issue 5858, pp. 1923-1927
DOI: 10.1126/science.1147554

Article Information

vol. 318 no. 5858 1923-1927

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Print ISSN: 
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History: 
  • Received for publication July 9, 2007
  • Accepted for publication October 31, 2007
  • .

Author Information

  1. Susanne Lutz1,*,
  2. Aruna Shankaranarayanan2,3,*,
  3. Cassandra Coco2,
  4. Marc Ridilla2,,
  5. Mark R. Nance2,
  6. Christiane Vettel1,
  7. Doris Baltus1,
  8. Chris R. Evelyn4,
  9. Richard R. Neubig4,
  10. Thomas Wieland1,,
  11. John J. G. Tesmer2,4,
  1. 1 Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, University of Heidelberg, Maybachstrasse 14, D-68169 Mannheim, Germany.
  2. 2 Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109–2216, USA.
  3. 3 Department of Chemistry and Biochemistry, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712–0165, USA.
  4. 4 Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109–0632, USA.
  1. To whom correspondence should be addressed. E-mail: tesmerjj{at}umich.edu (J.J.G.T.); thomas.wieland{at}urz.uniheidelberg.de (T.W.)
  • * These authors contributed equally to this work.

  • Present address: Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907, USA.

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