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A Mouse Model of Mitochondrial Disease Reveals Germline Selection Against Severe mtDNA Mutations

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Science  15 Feb 2008:
Vol. 319, Issue 5865, pp. 958-962
DOI: 10.1126/science.1147786

Article Information

vol. 319 no. 5865 958-962

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication July 13, 2007
  • Accepted for publication December 19, 2007
  • .

Author Information

  1. Weiwei Fan1,2,
  2. Katrina G. Waymire1,2,
  3. Navneet Narula3,
  4. Peng Li4,
  5. Christophe Rocher1,2,
  6. Pinar E. Coskun1,2,
  7. Mani A. Vannan4,
  8. Jagat Narula4,
  9. Grant R. MacGregor1,5,6,
  10. Douglas C. Wallace1,2,7,*
  1. 1 Center for Molecular and Mitochondrial Medicine and Genetics, University of California, Irvine, CA 92697, USA.
  2. 2 Department of Biological Chemistry, University of California, Irvine, CA 92697, USA.
  3. 3 Department of Pathology, University of California, Irvine, CA 92697, USA.
  4. 4 Division of Cardiology, Department of Medicine, University of California, Irvine, CA 92697, USA.
  5. 5 Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA.
  6. 6 Developmental Biology Center, University of California, Irvine, CA 92697, USA.
  7. 7 Departments of Ecology and Evolutionary Biology and Pediatrics, University of California, Irvine, CA 92697, USA.
  1. * To whom correspondence should be addressed. E-mail: dwallace{at}uci.edu

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