A Mouse Model of Mitochondrial Disease Reveals Germline Selection Against Severe mtDNA Mutations

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Science  15 Feb 2008:
Vol. 319, Issue 5865, pp. 958-962
DOI: 10.1126/science.1147786

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  • Why Germline Filters Out Severe mtDNA Mutations

    The interesting recent Report, "A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations" by W. Fan et al. (15 February 2008, p. 958) provides convincing evidence that mitochondrial mutations with severe effects are eliminated from the female germ line by selection within the ovary. We agree that such a "germline filter for severely deleterious mtDNA mutations makes evolutionary...

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    Competing Interests: None declared.