28 March 2008
Vol 319, Issue 5871

About The Cover

Cover image expansion

COVER The many layers of gene regulation in a eukaryotic cell, envisioned as a video game. Transcription in the nucleus (green circle) proceeds to translation in the cytoplasm via genome topology, polymerase pausing, microRNA repression, RNA splicing, and riboswitch regulation. See the special section beginning on page 1781.

Illustration: Carin L. Cain