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Tumor Regression in Cancer Patients by Very Low Doses of a T Cell–Engaging Antibody

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Science  15 Aug 2008:
Vol. 321, Issue 5891, pp. 974-977
DOI: 10.1126/science.1158545

Article Information

vol. 321 no. 5891 974-977

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History: 
  • Received for publication April 1, 2008
  • Accepted for publication July 7, 2008

Author Information

  1. Ralf Bargou1,2,*,
  2. Eugen Leo3,*,,
  3. Gerhard Zugmaier3,
  4. Matthias Klinger3,
  5. Mariele Goebeler1,2,
  6. Stefan Knop2,
  7. Richard Noppeney4,
  8. Andreas Viardot5,
  9. Georg Hess6,
  10. Martin Schuler7,
  11. Hermann Einsele2,
  12. Christian Brandl3,
  13. Andreas Wolf3,
  14. Petra Kirchinger3,
  15. Petra Klappers3,
  16. Margit Schmidt3,
  17. Gert Riethmüller8,
  18. Carsten Reinhardt3,
  19. Patrick A. Baeuerle3,,
  20. Peter Kufer3
  1. 1 Interdisciplinary Phase I/II Unit of the University of Würzburg, Klinikstraße 6-8, 97070 Würzburg, Germany.
  2. 2 Universitätsklinikum Würzburg, Medizinische Klinik und Poliklinik II, Klinikstraße 6-8, 97070 Würzburg, Germany.
  3. 3 Micromet AG, Staffelseestraße 2, 81477 Munich, Germany; and Micromet, Incorporated, 6707 Democracy Boulevard, Bethesda, MD 20817, USA.
  4. 4 Universitätsklinikum Essen, Klinik für Hämatologie, Medizinische Klinik und Poliklinik, Hufelandstraße 55, 45147 Essen, Germany.
  5. 5 Universitätsklinikum Ulm, Innere Medizin III, Robert-Koch-Straße 8, 89081 Ulm, Germany.
  6. 6 Klinikum der Johannes-Gutenberg Universität III, Medizinische Klinik und Poliklinik, Langenbeckstraße 1, 55131 Mainz, Germany.
  7. 7 Universitätsklinikum Essen, Innere Klinik (Tumorforschung), Tumorforschung, Hufelandstraße 55, 45122 Essen, Germany.
  8. 8 Institute for Immunology, Ludwig-Maximilians-Universität, Goethestraße 31, 81333 Munich, Germany.
  1. To whom correspondence should be addressed. E-mail: patrick.baeuerle{at}micromet-inc.com
  • * These authors contributed equally to this work.

  • Present address: Johnson and Johnson Pharmaceuticals, Turnhoutsebaan 30, 2340 Beerse, Belgium.

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