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Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

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Science  29 Aug 2008:
Vol. 321, Issue 5893, pp. 1218-1221
DOI: 10.1126/science.1158799

Article Information

vol. 321 no. 5893 1218-1221

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History: 
  • Received for publication April 7, 2008
  • Accepted for publication July 2, 2008

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Author Information

  1. John T. Dimos1,*,
  2. Kit T. Rodolfa1,2,*,
  3. Kathy K. Niakan1,
  4. Laurin M. Weisenthal1,
  5. Hiroshi Mitsumoto3,4,
  6. Wendy Chung4,5,
  7. Gist F. Croft4,6,
  8. Genevieve Saphier1,
  9. Rudy Leibel5,
  10. Robin Goland7,
  11. Hynek Wichterle4,6,
  12. Christopher E. Henderson4,6,
  13. Kevin Eggan1,
  1. 1 Harvard Stem Cell Institute, Stowers Medical Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
  2. 2 Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
  3. 3 Eleanor and Lou Gehrig MDA-ALS Research Center, Neurological Institute, Columbia University Medical Center, New York, NY 10032, USA.
  4. 4 Center for Motor Neuron Biology and Disease, Columbia University Medical Center, New York, NY 10032, USA.
  5. 5 Division of Molecular Genetics and Naomi Berrie Diabetes Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
  6. 6 Departments of Pathology, Neurology and Neuroscience, Columbia University Medical Center, New York, NY 10032, USA.
  7. 7 Department of Medicine and Naomi Berrie Diabetes Center, Columbia University Medical Center, New York, NY 10032, USA.
  1. To whom correspondence should be addressed. E-mail: eggan{at}mcb.harvard.edu
  • * These authors contributed equally to this work.

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