05 September 2008
Vol 321, Issue 5894

About The Cover

Cover image expansion

COVER Mammalian fatty acid synthase, a multienzyme that catalyzes all steps of fatty acid biosynthesis. A blueprint of its atomic structure is shown in three views, and the extent of its functional domains is indicated by colored bars. The versatile segmental construction is also used in other members of this large family of multienzymes, which synthesize natural products such as antibiotics. See page 1315. Image: Marc Leibundgut and Timm Maier/ETH Zurich