Life Cycle of Translational Research for Medical Interventions

Despina G. Contopoulos-Ioannidis; George A. Alexiou; Theodore C. Gouvias; John P. A. Ioannidis

doi:10.1126/science.1160622

Policy ForumMedicine

Life Cycle of Translational Research for Medical Interventions

Despina G. Contopoulos-Ioannidis¹,
George A. Alexiou²,
Theodore C. Gouvias²,
John P. A. Ioannidis²,³,⁴,*

¹Department of Pediatrics, University of Ioannina School of Medicine, Ioannina, 45110, Greece, and Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA
²Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, 45110, Greece
³Department of Medicine, Tufts Medical Center, and Institute for Clinical Research and Health Policy Studies, Tufts University School of Medicine, Boston, MA 02111, USA
⁴Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina 45110, Greece

↵*Author for correspondence (at the address in footnote 2). E-mail: jioannid{at}cc.uoi.gr; john.pa.ioannidis{at}gmail.com

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Science 05 Sep 2008:
Vol. 321, Issue 5894, pp. 1298-1299
DOI: 10.1126/science.1160622

Despina G. Contopoulos-Ioannidis

1Department of Pediatrics, University of Ioannina School of Medicine, Ioannina, 45110, Greece, and Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA

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George A. Alexiou

2Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, 45110, Greece

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Theodore C. Gouvias

2Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, 45110, Greece

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John P. A. Ioannidis

2Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, 45110, Greece

3Department of Medicine, Tufts Medical Center, and Institute for Clinical Research and Health Policy Studies, Tufts University School of Medicine, Boston, MA 02111, USA

4Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina 45110, Greece

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For correspondence: jioannid@cc.uoi.gr john.pa.ioannidis@gmail.com

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Summary

From the initial discovery of a medical intervention to a highly cited article is a long road, and even this is not the end of the journey.

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Life Cycle of Translational Research for Medical Interventions

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