Research Article

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

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Science  26 Sep 2008:
Vol. 321, Issue 5897, pp. 1801-1806
DOI: 10.1126/science.1164368

Article Information

vol. 321 no. 5897 1801-1806

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History: 
  • Received for publication August 7, 2008
  • Accepted for publication August 27, 2008

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Author Information

  1. Siân Jones1,*,
  2. Xiaosong Zhang1,*,
  3. D. Williams Parsons1,2,*,
  4. Jimmy Cheng-Ho Lin1,*,
  5. Rebecca J. Leary1,*,
  6. Philipp Angenendt1,*,
  7. Parminder Mankoo3,
  8. Hannah Carter3,
  9. Hirohiko Kamiyama4,
  10. Antonio Jimeno1,
  11. Seung-Mo Hong4,
  12. Baojin Fu4,
  13. Ming-Tseh Lin4,
  14. Eric S. Calhoun1,
  15. Mihoko Kamiyama4,
  16. Kimberly Walter4,
  17. Tatiana Nikolskaya5,
  18. Yuri Nikolsky6,
  19. James Hartigan7,
  20. Douglas R. Smith7,
  21. Manuel Hidalgo1,
  22. Steven D. Leach1,8,
  23. Alison P. Klein1,4,
  24. Elizabeth M. Jaffee1,4,
  25. Michael Goggins1,4,
  26. Anirban Maitra1,4,
  27. Christine Iacobuzio-Donahue1,4,
  28. James R. Eshleman1,4,
  29. Scott E. Kern1,4,
  30. Ralph H. Hruban1,4,
  31. Rachel Karchin3,
  32. Nickolas Papadopoulos1,
  33. Giovanni Parmigiani1,9,
  34. Bert Vogelstein1,,
  35. Victor E. Velculescu1,,
  36. Kenneth W. Kinzler1,
  1. 1 Sol Goldman Pancreatic Cancer Research Center, Ludwig Center and Howard Hughes Medical Institute at the Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.
  2. 2 Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX 77030, USA.
  3. 3 Department of Biomedical Engineering, Institute of Computational Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21218, USA.
  4. 4 Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.
  5. 5 Vavilov Institute for General Genetics, Moscow B333, 117809, Russia.
  6. 6 GeneGo, Incorporated, St. Joseph, MI 49085, USA.
  7. 7 Agencourt Bioscience Corporation, Beverly, MA 01915, USA.
  8. 8 Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.
  9. 9 Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
  1. To whom correspondence should be addressed. E-mail: bertvog{at}gmail.com (B.V.); velculescu{at}jhmi.edu (V.E.V.); kinzlke{at}jhmi.edu (K.W.K.)
  • * These authors contributed equally to this work.

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