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Functional Targeting of DNA Damage to a Nuclear Pore-Associated SUMO-Dependent Ubiquitin Ligase

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Science  24 Oct 2008:
Vol. 322, Issue 5901, pp. 597-602
DOI: 10.1126/science.1162790

Article Information

vol. 322 no. 5901 597-602

PubMed: 
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History: 
  • Received for publication July 7, 2008
  • Accepted for publication September 16, 2008
  • .

Author Information

  1. Shigeki Nagai1,2,*,
  2. Karine Dubrana2,*,,
  3. Monika Tsai-Pflugfelder1,
  4. Marta B. Davidson3,
  5. Tania M. Roberts3,
  6. Grant W. Brown3,
  7. Elisa Varela1,
  8. Florence Hediger2,
  9. Susan M. Gasser1,2,,
  10. Nevan J. Krogan4
  1. 1 Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.
  2. 2 Department of Molecular Biology and National Center of Competence in Research Frontiers in Genetics, 30 Quai Ernest Ansermet, 1211 Geneva, Switzerland.
  3. 3 Department of Biochemistry, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.
  4. 4 Department of Cellular and Molecular Pharmacology, California Institute for Quantitative Biomedical Research, University of California, San Francisco, 1700 Fourth Street, San Francisco, CA 94158, USA.
  1. To whom correspondence should be addressed. E-mail: susan.gasser{at}fmi.ch
  • * These authors contributed equally to this work.

  • Present address: UMR218, Institut Curie/Section de Recherche, 26 Rue d'Ulm, 75231 Paris, and Institut de Radiobiologie Cellulaire et Moléculaire, CEA, 92265 Fontenay aux Roses, France.

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