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Cytosolic Viral Sensor RIG-I Is a 5'-Triphosphate–Dependent Translocase on Double-Stranded RNA

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Science  20 Feb 2009:
Vol. 323, Issue 5917, pp. 1070-1074
DOI: 10.1126/science.1168352

Article Information

vol. 323 no. 5917 1070-1074

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History: 
  • Received for publication November 11, 2008
  • Accepted for publication December 15, 2008
  • .

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Author Information

  1. Sua Myong1,*,,
  2. Sheng Cui2,*,
  3. Peter V. Cornish3,4,
  4. Axel Kirchhofer2,
  5. Michaela U. Gack5,6,7,
  6. Jae U. Jung5,6,
  7. Karl-Peter Hopfner2,,
  8. Taekjip Ha1,3,4,
  1. 1 Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 West Gregory Drive, Champaign, IL 61801, USA.
  2. 2 Center for Integrated Protein Science and Munich Center for Advanced Photonics at the Gene Center, Ludwig-Maximilians-University of Munich, Feodor-Lynen-Strasse 25, 81377 Munich, Germany.
  3. 3 Department of Physics and Center for the Physics of Living Cells, University of Illinois at Urbana-Champaign, Room 133, Loomis Laboratory, MC 704, 1110 West Green Street, Urbana, IL 61801, USA.
  4. 4 Howard Hughes Medical Institute, Urbana, IL, USA.
  5. 5 Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Harlyne J. Norris Cancer Research Tower, 1450 Biggy Street, Los Angeles, CA 90033, USA.
  6. 6 Department of Microbiology and Molecular Genetics and Tumor Virology Division, New England Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, MA 01772, USA.
  7. 7 Institute for Clinical and Molecular Virology, Friedrich-Alexander-University Erlangen-Nuremberg, Schlossgarten 4, 91054 Erlangen, Germany.
  1. To whom correspondence should be addressed. E-mail: smyong{at}uiuc.edu (S.M.); hopfner{at}lmb.uni-muenchen.de (K.-P.H.); tjha{at}uiuc.edu (T.H.)
  • * These authors contributed equally to this work.

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