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Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

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Science  27 Feb 2009:
Vol. 323, Issue 5918, pp. 1205-1208
DOI: 10.1126/science.1166066

Article Information

vol. 323 no. 5918 1205-1208

PubMed: 
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History: 
  • Received for publication September 17, 2008
  • Accepted for publication January 6, 2009
  • .

Author Information

  1. T. J. Kwiatkowski Jr.1,*,
  2. D. A. Bosco1,2,
  3. A. L. LeClerc1,2,
  4. E. Tamrazian1,
  5. C. R. Vanderburg3,
  6. C. Russ1,4,
  7. A. Davis1,
  8. J. Gilchrist5,
  9. E. J. Kasarskis6,
  10. T. Munsat7,,
  11. P. Valdmanis8,
  12. G. A. Rouleau8,
  13. B. A. Hosler1,
  14. P. Cortelli9,
  15. P. J. de Jong10,
  16. Y. Yoshinaga10,
  17. J. L. Haines11,
  18. M. A. Pericak-Vance12,
  19. J. Yan13,
  20. N. Ticozzi1,2,14,
  21. T. Siddique13,
  22. D. McKenna-Yasek1,
  23. P. C. Sapp1,15,
  24. H. R. Horvitz15,
  25. J. E. Landers1,2,
  26. R. H. Brown Jr.1,2,*
  1. 1 Department of Neurology, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA.
  2. 2 Department of Neurology, University of Massachusetts School of Medicine, Worcester, MA 01655, USA.
  3. 3 Massachusetts General Institute for Neurodegeneration, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA.
  4. 4 Broad Institute, Massachusetts Institute of Technology (MIT), Cambridge, MA 02141, USA.
  5. 5 Department of Neurology, Rhode Island Hospital, Providence, RI 02192, USA.
  6. 6 Department of Neurology, Veterans Affairs Medical Center, University of Kentucky, Lexington, KY 40511, USA.
  7. 7 Department of Neurology, Tufts New England Medical Center, Tufts University, Boston, MA 02111, USA.
  8. 8 Department of Neurology, Centre de Recherche du Centre Hospitalier de l'Université de Montreal, University of Montreal, Quebec H2L 4M1, Canada.
  9. 9 Clinica Neurologica, Departimento di Scienze Neurologiche, University de Bologna, Via Ugo Foscola, 7,40123 Bologna, Italy.
  10. 10 Childrens' Hospital Oakland Research Institute, Oakland, CA 94609, USA.
  11. 11 Center for Human Genetics Research, Molecular Physiology and Biophyscis, Vanderbilt University, Nashville, TN 37240, USA.
  12. 12 Miami Institute of Human Genetics, Miami, FL 33136, USA
  13. 13 Departments of Neurology and Molecular and Cellular Biology, Northwestern Feinberg School of Medicine, Chicago, IL 60611, USA.
  14. 14 Department of Neurology, University of Milan Medical School, Dino Ferrari Center, Istituto Auxologico Italiano, Milan 20149, Italy.
  15. 15 Department of Biology, Howard Hughes Medical Institute, MIT, Cambridge, MA 02139, USA.
  1. * To whom correspondence should be addressed. E-mail: tkwiatkowski{at}partners.org (T.J.K.); robert.brown{at}umassmed.edu (R.H.B.)
  • Retired.

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