Report

Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis

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Science  27 Feb 2009:
Vol. 323, Issue 5918, pp. 1215-1218
DOI: 10.1126/science.1167498

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  • Response to J.-M. Frère and K. Bush's E-Letter

    J.-M. Frère and K. Bush believe that we incorrectly treated the inhibition by meropenem of nitrocefin hydrolysis catalyzed by BlaC, and specifically that we used an incorrect model. We used a standard treatment that they term model 2 in the Supporting Online Material to the Report ("Meropenem-Clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis," 27 February 2009, p. 1215) to describe...

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    Competing Interests: None declared.
  • β-Lactamase Kinetics Revisited

    J.-E. Hugonnet et al. ("Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis," Reports, 27 February 2009, p. 1215) analyze the interaction between the β-lactamase of Mycobacterium tuberculosis and meropenem according to two distinct and incompatible kinetic models in the Supporting Online Material (SOM) and the Report. Only the latter is correct. The analysi...

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    Competing Interests: None declared.