Report

Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer

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Science  08 May 2009:
Vol. 324, Issue 5928, pp. 787-790
DOI: 10.1126/science.1168175

Article Information

vol. 324 no. 5928 787-790

PubMed: 
Print ISSN: 
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History: 
  • Received for publication November 6, 2008
  • Accepted for publication March 13, 2009

Article Versions

Author Information

  1. Chris Tran1,*,
  2. Samedy Ouk5,*,
  3. Nicola J. Clegg1,
  4. Yu Chen1,3,
  5. Philip A. Watson1,
  6. Vivek Arora1,
  7. John Wongvipat1,
  8. Peter M. Smith-Jones2,
  9. Dongwon Yoo5,
  10. Andrew Kwon1,
  11. Teresa Wasielewska1,
  12. Derek Welsbie6,
  13. Charlie Degui Chen6,,
  14. Celestia S. Higano7,
  15. Tomasz M. Beer8,
  16. David T. Hung9,
  17. Howard I. Scher3,
  18. Michael E. Jung5,,
  19. Charles L. Sawyers1,4,
  1. 1Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
  2. 2Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
  3. 3Genitourinary Oncology Service, Division of Solid Tumor Oncology and Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
  4. 4Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
  5. 5Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USA.
  6. 6Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA.
  7. 7Division of Oncology, Departments of Medicine and Urology, University of Washington, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  8. 8OHSU Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA.
  9. 9Medivation, Inc., 201 Spear Street, San Francisco, CA 94105, USA.
  1. To whom correspondence should be addressed. E-mail: sawyersc{at}mskcc.org; jung{at}chem.ucla.edu

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