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Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

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Science  08 May 2009:
Vol. 324, Issue 5928, pp. 801-804
DOI: 10.1126/science.1171583

Article Information

vol. 324 no. 5928 801-804

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History: 
  • Received for publication January 29, 2009
  • Accepted for publication March 13, 2009

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Author Information

  1. Vadim Makarov1,2,*,
  2. Giulia Manina1,3,*,
  3. Katarina Mikusova1,4,*,
  4. Ute Möllmann1,5,*,
  5. Olga Ryabova1,2,
  6. Brigitte Saint-Joanis1,6,
  7. Neeraj Dhar7,
  8. Maria Rosalia Pasca1,3,
  9. Silvia Buroni1,3,
  10. Anna Paola Lucarelli1,3,
  11. Anna Milano1,3,
  12. Edda De Rossi1,3,
  13. Martina Belanova1,4,
  14. Adela Bobovska1,4,
  15. Petronela Dianiskova1,4,
  16. Jana Kordulakova1,4,
  17. Claudia Sala1,7,
  18. Elizabeth Fullam1,7,
  19. Patricia Schneider1,7,
  20. John D. McKinney7,
  21. Priscille Brodin8,
  22. Thierry Christophe8,
  23. Simon Waddell1,9,
  24. Philip Butcher1,9,
  25. Jakob Albrethsen1,10,
  26. Ida Rosenkrands1,10,
  27. Roland Brosch1,6,
  28. Vrinda Nandi1,11,
  29. Sowmya Bharath1,11,
  30. Sheshagiri Gaonkar1,11,
  31. Radha K. Shandil1,11,
  32. Venkataraman Balasubramanian1,11,
  33. Tanjore Balganesh1,11,
  34. Sandeep Tyagi12,
  35. Jacques Grosset12,
  36. Giovanna Riccardi1,3,
  37. Stewart T. Cole1,7,
  1. 1New Medicines for Tuberculosis (NM4TB) Consortium (www.nm4tb.org).
  2. 2A. N. Bakh Institute of Biochemistry, Russian Academy of Science, 119071 Moscow, Russia.
  3. 3Dipartimento di Genetica e Microbiologia, Università degli Studi di Pavia, via Ferrata, 1, 27100 Pavia, Italy.
  4. 4Department of Biochemistry, Faculty of Natural Sciences, Comenius University, Mlynska dolina, 84215 Bratislava, Slovakia.
  5. 5Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology–Hans Knoell Institute, Beutenbergstrasse 11a, D-07745 Jena, Germany.
  6. 6Institut Pasteur, Integrated Mycobacterial Pathogenomics, 25-28, Rue du Docteur Roux, 75724 Paris Cedex 15, France.
  7. 7Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
  8. 8Inserm Avenir Group, Institut Pasteur Korea, 39-1 Hawolgok-dong, Seongbuk-gu, 136-791 Seoul, Korea.
  9. 9Division of Cellular and Molecular Medicine, St. George’s Hospital, University of London, Cranmer Terrace, SW17 ORE London, UK.
  10. 10Statens Serum Institut, Department of Infectious Disease Immunology, Artillerivej 5, DK-2300 Copenhagen S, Denmark.
  11. 11AstraZeneca India, Bellary Road Hebbal, Bangalore, India.
  12. 12Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  1. To whom correspondence should be addressed. E-mail: stewart.cole{at}epfl.ch

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