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Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

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Science  15 May 2009:
Vol. 324, Issue 5929, pp. 930-935
DOI: 10.1126/science.1170116

Article Information

vol. 324 no. 5929 930-935

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Print ISSN: 
Online ISSN: 
History: 
  • Received for publication December 22, 2008
  • Accepted for publication April 3, 2009
  • .

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Author Information

  1. Mamta Tahiliani1,
  2. Kian Peng Koh1,
  3. Yinghua Shen2,
  4. William A. Pastor1,
  5. Hozefa Bandukwala1,
  6. Yevgeny Brudno2,
  7. Suneet Agarwal3,
  8. Lakshminarayan M. Iyer4,
  9. David R. Liu2,*,
  10. L. Aravind4,* and
  11. Anjana Rao1,*
  1. 1Department of Pathology, Harvard Medical School and Immune Disease Institute, 200 Longwood Avenue, Boston, MA 02115, USA.
  2. 2Department of Chemistry and Chemical Biology and the Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
  3. 3Division of Pediatric Hematology/Oncology, Children’s Hospital Boston and Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  4. 4National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
  1. *To whom correspondence should be addressed. E-mail: arao{at}idi.harvard.edu (A.R.); aravind{at}ncbi.nlm.nih.gov (L.A.); drliu{at}fas.harvard.edu (D.R.L.)

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