Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

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Science  22 May 2009:
Vol. 324, Issue 5930, pp. 1029-1033
DOI: 10.1126/science.1160809

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  • Response to W. H. Koppenol and P. L. Bounds' E-Letter

    W. H. Koppenol and P. L. Bounds highlight an often misunderstood feature of proliferative cell metabolism. There is substantial evidence demonstrating oxidative phosphorylation persists in the vast majority, if not all, tumors. We argued recently that continued oxidative phosphorylation was indeed associated with tumor cell metabolism (1) and depicted in Figure 2 of our Review that at least 5% of the glucose in prolife...

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    Competing Interests: None declared.
  • The Warburg Effect and Metabolic Efficiency: Re-crunching the Numbers

    M. G. Vander Heiden et al. addressed the question of why a cell would "choose" glycolysis over oxidative phosphorylation, whereby only 2 instead of 36 adenosine 5'-triphosphate (ATP) are obtained per glucose molecule ("Understanding the Warburg Effect: The metabolic requirements of cell proliferation," Reviews, 22 May 2009, p. 1029). However, the question, as well as the proffered explanations, misses the point of War...

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    Competing Interests: None declared.

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